Figure 1. A PI3K inhibitor, BKM120, enhances the radiosensitization of hepatocellular carcinoma cell lines (Huh7 and BNL).

(A) Quantitative results of clonogenic assays after combination treatment with BKM120 and irradiation. The images (magnified 100X) were used to count colonies containing more than 50 cells. At each dose level, the colony count is expressed as a fraction of the number in the corresponding control group. Lines, mean (n=3); Bars, S.D. (B) Combination indices (CI) are plotted against cell fraction affected (Fa). CI values <1 indicate synergism.