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. 2014 May 20;5(11):3756–3769. doi: 10.18632/oncotarget.1993

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Copyright: © 2014 Zhen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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MACC1 over-expression significantly promoted tumor growth of HCT116 cells implanted subcutaneously in BALB/c-nu mice compared with the control group (p<0.001; A, B-upper) and significantly increased tumor weight (P<0.001; B-lower). MACC1 knockdown significantly suppressed tumor growth of SW620 cells at a density of 1×10⁶/100μl (C-D) and 2×10⁶/100μl (E-F) implanted subcutaneously in BALB/c-nu mice compared with the control group and significantly reduced tumor weight, respectively.