Figure 2. The androgen receptor is a potential transcription factor downstream of AMPK.

A: Ingenuity Pathway analysis was used to predict significantly enriched transcriptional regulators among differentially expressed genes following 24 h of AICAR or metformin treatment. B: AMPK target genes were compared to two published datasets describing AR target genes [11, 60]. The overlap between gene lists is depicted as an area-proportional Venn diagram. Hypergeometric test was performed to test significance of overlaps between treatments. Examples of genes regulated by AMPK and by AR in at least one dataset are shown.