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. 2014 May 24;5(11):3823–3835. doi: 10.18632/oncotarget.1709

Figure 4. P5 and P6 peptides inhibit VEGF-C/VEGFR-3 signaling and cell mobility in LECs and multiple cancer cells.

Figure 4

(A) Effects of P4, P5 and P6 peptides on VEGF-C-induced VEGFR-3 phosphorylation, migration and proliferation in LECs were analyzed by western blot analysis, Boyden chamber assay and MTT assay. The statistically significant in the MTT assay mean compared with the indicated group at 96 hrs. (B-E) Effects of P4, P5 and P6 peptides on VEGF-C-induced VEGFR-3 phosphorylation was analyze by western blot analysis (upper) and the ability of migration and invasion (lower) in cancer cells. MDA-MB-231 (B), BT474 (C), CL1-5 (D) and H460 (E). Columns, mean of three independent experiments; bars, SD. **, p < 0.01; ***, p < 0.001 statistically significant decrease compared with the corresponding control value.