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. 2014 May 22;5(11):3836–3848. doi: 10.18632/oncotarget.1657

Figure 7. C96 delays myeloma tumor growth in a xenograft mouse model.

Figure 7

(A) JJN3 cells were injected subcutaneously into nude mice with a density of 30 million cells/site/mouse. When tumors were palpable, mice (n=5/group) were orally given C96 (100 mg/kg body weight) in PBS containing 10% Tween 80 and 10% DMSO daily for continuous 16 days. Tumor volumes were monitored every other day. (B) Mouse body weight was monitored every other day. (C) At the end of the experiment, tumor samples from each group were subjected to immunoblotting analysis for the expression levels of p-AKT, T-AKT, p-mTOR and mTOR with specific antibodies. GAPDH was used as a loading control.