Table 1b. Pathways affected by vitamin D supplementation.

Signal Pathway		odds radio (loge)	p value	Adjusted p value
Up regulated
	Metabolism of xenobiotics by P450	2.58	<0.0001	<0.0001
	Drug metabolism - P450	2.87	<0.0001	<0.0001
	Metabolic pathways	1.20	<0.0001	<0.0001
	Primary bile acid biosynthesis	3.39	<0.0001	<0.0001
	PPAR signaling pathway	2.53	<0.0001	<0.0001
	Glycosphingolipid biosynthesis	2.85	0.0017	0.0192
	Retinol metabolism	2.97	<0.0001	<0.0001
	Linoleic acid metabolism	3.33	<0.0001	<0.0001
	Drug metabolism	2.36	<0.0001	0.0003
	Arachidonic acid metabolism	2.40	<0.0001	<0.0001
Down regulated
	Retinol metabolism	1.90	0.0005	0.0265
	ABC transporters	2.19	0.0005	0.0265
	Biosynthesis of unsaturated fatty acids	2.21	0.0017	0.0449
	Tyrosine metabolism	2.38	0.0002	0.0265
	Focal adhesion	1.33	0.0011	0.0337
	Taste transduction	1.83	0.0020	0.0470
	mTOR signaling pathway	2.15	0.0006	0.0265
	Glycosaminoglycan biosynthesis	3.02	0.0010	0.0337