Table 1.
List of Significantly Up-Regulated and Down-Regulated Genes in L-ID4 Compared With Those in L+ns Control Cells
| Gene Symbol | Entrez Gene Name | Location | Type | Fold Regulation |
|---|---|---|---|---|
| DDIT3 | DNA-damage-inducible transcript 3 | Nucleus | Transcription regulator | 15.6465 |
| AMACR | α-Methylacyl-CoA racemase | Cytoplasm | Enzyme | 6.4582 |
| PRSS1 | Protease, serine,1 (trypsin 1) | Extracellular space | Peptidase | 6.1290 |
| SLC26A3 | Solute carrier family 26, member 3 | Plasma membrane | Transporter | 6.0425 |
| CDKN1C | Cyclin-dependent kinase inhibitor 1C (p57, Kip2) | Nucleus | Other | 5.1054 |
| RGS2 | Regulator of G-protein signaling 2, 24 kDa | Nucleus | Other | 4.4968 |
| DIO1 | Deiodinase, iodothyronine, type I | Cytoplasm | Enzyme | 4.1950 |
| S100P | S100 calcium binding protein P | Cytoplasm | Other | 3.7255 |
| SYCE3 | Synaptonemal complex central element protein 3 | Nucleus | Other | 3.6100 |
| SAT1 | Spermidine/spermine N1-acetyltransferase 1 | Cytoplasm | Enzyme | 3.3894 |
| CRISP3 | Cysteine-rich secretory protein 3 | Extracellular space | Other | 3.3368 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | Plasma membrane | Other | 3.0587 |
| SYT4 | Synaptotagmin IV | Cytoplasm | Transporter | 3.0510 |
| ALDOC | Aldolase C, fructose-bisphosphate | Cytoplasm | Enzyme | 2.9990 |
| NUPR1 | Nuclear protein, transcriptional regulator, 1 | Nucleus | Transcription regulator | 2.9928 |
| ALDH1A3 | Aldehyde dehydrogenase 1 family, member A3 | Cytoplasm | Enzyme | 2.9411 |
| NDRG1 | N-myc downstream regulated 1 | Nucleus | Kinase | 2.9277 |
| GDF15 | Growth differentiation factor 15 | Extracellular space | Growth factor | 2.8433 |
| MCM5 | Minichromosome maintenance complex component 5 | Nucleus | Enzyme | −2.7266 |
| TMEM179B | Transmembrane protein 179B | Other | Other | −2.7503 |
| TUBA1A | Tubulin, α 1a | Cytoplasm | Other | −2.8099 |
| RPN1 | Ribophorin I | Cytoplasm | Enzyme | −2.8183 |
| GPX4 | Glutathione peroxidase 4 | Cytoplasm | Enzyme | −2.8186 |
| NUP188 | Nucleoporin 188 kDa | Nucleus | Other | −2.8307 |
| ATP6V0B | ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit b | Cytoplasm | Transporter | −2.8322 |
| YEATS4 | YEATS domain containing 4 | Nucleus | Transcription regulator | −2.8511 |
| CDCA5 | Cell division cycle associated 5 | Cytoplasm | Other | −2.9944 |
| FH | Fumarate hydratase | Cytoplasm | Enzyme | −3.0990 |
| RNF26 | Ring finger protein 26 | Other | Other | −3.2874 |
| RNF114 | Ring finger protein 114 | Extracellular space | Other | −3.3081 |
| LDLR | Low-density lipoprotein receptor | Plasma membrane | Transporter | −3.3277 |
| MRPL16 | Mitochondrial ribosomal protein L16 | Cytoplasm | Other | −3.5228 |
| CDCA7 | Cell division cycle associated 7 | Nucleus | Other | −3.5235 |
| RPS15 | Ribosomal protein S15 | Cytoplasm | Other | −3.5653 |
| TUBB4B | Tubulin, β 4B class IVb | Cytoplasm | Other | −3.6613 |
| HIST1H1B | Histone cluster 1, H1b | Nucleus | Other | −3.7330 |
| PTMA | Prothymosin, α | Nucleus | Other | −4.3649 |
| LSM7 | LSM7 homolog, U6 small nuclear RNA associated (Saccharomyces cerevisiae) | Nucleus | Other | −4.5048 |
| NDUFS7 | NADH dehydrogenase (ubiquinone) | Cytoplasm | Enzyme | −5.7413 |
| ID3 | Inhibitor of DNA binding 3, helix-loop-helix protein | Nucleus | Transcription regulator | −9.0171 |
| TXNIP | Thioredoxin interacting protein | Cytoplasm | Other | −11.0709 |