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. Author manuscript; available in PMC: 2014 Jul 31.
Published in final edited form as: Nat Genet. 2012 Sep 30;44(11):1231–1235. doi: 10.1038/ng.2424

Table 1.

Summary results of associations with prostate cancer risk at 9q31.2 and 19q13.4 in Chinese men

Marker Allelesa Location Gene Study Genotypesb
 MAFc
 OR
(95% CI)d 		Pd
Cases Controls Cases Controls
rs817826 T/C 9q31.2 RAD23B KLF4 GWAS 1,128/275/14 860/144/4 0.107 0.075 1.43 (1.17–1.77) 6.82 × 10−4
Replication 1 619/154/9 1,513/264/14 0.110 0.082 1.39 (1.14–1.70) 1.05 × 10−3
Replication 2 858/226/18 3,770/701/27 0.119 0.084 1.47 (1.27–1.71) 3.09 × 10−7
Replication 3 927/234/10 1,368/251/12 0.109 0.084 1.33 (1.11–1.59) 2.22 × 10−3
Combinede 1.41 (1.29–1.54) 5.45 × 10−14
rs103294 T/C 19q13.4 LILRA3 GWAS 701/579/137 579/371/58 0.301 0.242 1.28 (1.12–1.45) 2.94 × 10−4
Replication 1 388/311/82 1,036/655/97 0.304 0.237 1.40 (1.23–1.60) 4.98 × 10−7
Replication 2 577/430/94 2,621/1,609/263 0.281 0.238 1.25 (1.13–1.39) 2.62 × 10−5
Replication 3 602/485/85 943/592/90 0.279 0.238 1.25(1.11−1.41) 3.65 × 10−4
Combinede 1.28(1.21−1.36) 5.34 × 10−16
a

Major allele/minor allele.

b

Major homozygotes/heterozygotes/minor homozygotes.

c

Minor allele frequency (MAF).

d

ORs, 95% CIs and corresponding P values in an additive model were estimated using a logistic regression model.

e

Results in an additive model from GWAS and replication stages were combined by meta-analysis using a fixed-effect model under the absence of heterogeneity among studies for both loci (rs817826: P = 0.83, I2 = 0; rs103294: P = 0.53, I2 = 0).