Table 5.
Population pharmacokinetics analysis.
| Parameters | Weight-based model, estimate (%CV) | Final model with OCT-dependent CL, estimate (%CV) | Bootstrap value, median (%CV) |
|---|---|---|---|
| Fixed effects | |||
| CL (l/min) | 1.2 (9.7) | 1.2 (9.9) | 1.2 (10.5) |
| Factor for OCT1 homozygotes | – | 0.83 (6.2) | 0.83 (6.4) |
| V1 (l) | 3.9 (38.9) | 3.9 (38.5) | 4.0 (36) |
| Q (l/min) | 1.6 (32.3) | 1.6 (32.1) | 1.6 (30.2) |
| V2 (l) | 21.3 (22.3) | 21.2 (22.3) | 20.9 (21.9) |
| γ CL | 0.75 | 0.75 | 0.75 |
| γ V1 | 1 | 1 | 1 |
| γ Q | 0.75 | 0.75 | 0.75 |
| γ V2 | 1 | 1 | 1 |
| Interindividual variability | |||
| Omega on CL | 0.1826 (13.2) | 0.173 (14.3) | 0.172 (29.9) |
| Residual error | |||
| Proportional | 0.2464 (9.7) | 0.2478 (9.7) | 0.245 (19.3) |
All reported pharmacokinetic parameters are for a standard adult weighing 70 kg.
γCL: Allometric coefficient for clearance; γQ; Allometric coefficient for intercompartmental clearance; γv1: Allometric coefficient for central volume; γV2: Allometric coefficient for peripheral volume; CL: Clearance; CV: Coefficient of variation; Q: Intercompartmental clearance; V1: Central volume; V2: Peripheral volume.