Table 3.
Immune Suppression in Response to Sepsis
| Organs | WT | β-Arr1−/− | β-Arr1+/− |
|---|---|---|---|
| Splenocytes | |||
| IL-6 | 9.7 ± 3.3 | 6.5 ± 2.6 | 51.9 ± 42.6 |
| TNFα | 36.8 ± 19.2 | 15.2 ± 7.6 | 45.9 ± 30.1 |
| IFN-γ | 4.6 ± 2.2 | 1.1 ± 0.2 | 8.9 ± 2.3 |
| Peritoneal cells | |||
| IL-6 | 7.6 ± 5.1 | 10.7 ± 4.8 | 3.8 ± 0.9 |
| TNFα | 5.3 ± 2.1 | 25.2 ± 12.3 | 3.6 ± 0.7 |
| IFN-γ | 37.2 ± 27.3 | 36.3 ± 29.5 | 5.2 ± 2.2 |
Cytokine production by splenocytes and peritoneal cells following ex vivo lipopolysaccharide stimulation shown as fold change over unstimulated cells for each mouse. n = 6 to 8 mice for each genotype with data pooled from two independent experiments.
WT, wild type.