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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Free Radic Biol Med. 2014 Jun 9;73:299–307. doi: 10.1016/j.freeradbiomed.2014.06.001

FIGURE 6. ICV-administered non-reducible cl-nanozyme decreases blood pressure in AngII-dependent hypertensive mice.

FIGURE 6

Mean data showing AngII-induced changes in mean arterial pressure (A), heart rate (B), systolic blood pressure (C) and diastolic blood pressure (D) following subcutaneous infusion of AngII (400ng/kg/min) and changes in these physiological parameters after a single bolus ICV injection of saline, PLL50-PEG shell, reducible cl-nanozyme, or non-reducible cl-nanozyme (130–150 U of CuZnSOD was used for nanozyme treatments). n = 5–7 mice per group. Data represent mean ± SEM. * P < 0.05 vs. ICV-injected saline; # P = 0.085 vs. ICV-injected saline.