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. Author manuscript; available in PMC: 2014 Jul 31.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Jan 13;17(6):1634–1640. doi: 10.1016/j.bmcl.2006.12.114

Table 2.

ATX inhibitory evaluation of compound g1 – g15

graphic file with name nihms20052t24.jpg
Compounds R *S/R ATX activity (%)
1 µM 10 µM 100 µM
g1 graphic file with name nihms20052t25.jpg R 85 70 57
g2 graphic file with name nihms20052t26.jpg S 79 68 44
g3 graphic file with name nihms20052t27.jpg R N/D 82 76
g4 graphic file with name nihms20052t28.jpg S N/D 71 61
g5 graphic file with name nihms20052t29.jpg R 78 68 52
g6 graphic file with name nihms20052t30.jpg S 102 72 50
g7 graphic file with name nihms20052t31.jpg S 71 74 26
g8 CH3 R 84 71 32
g9 CH3 S 96 68 45
g10 n-C3H7 R 104 97 75
g11 n-C3H7 S N/D 97 72
g12 n-C5H11 R 93 84 N/D
g13 n-C5H11 S 95 83 N/D
g14 graphic file with name nihms20052t32.jpg R 97 101 76
g15 graphic file with name nihms20052t33.jpg S 104 104 85