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. Author manuscript; available in PMC: 2014 Jul 31.
Published in final edited form as: Bioorg Med Chem Lett. 2007 Jan 13;17(6):1634–1640. doi: 10.1016/j.bmcl.2006.12.114

Table 3.

ATX inhibitory evaluation of compound f35 – f44

graphic file with name nihms20052t34.jpg
Compounds R * S/R ATX activity (%)
1 µM 10 µM 10 µM
f35 n-C9H19 R (a1) N/D 86 30
f36 n-C9H19 R (b1) N/D N/D N/D
f37 n-C13H27 R (a) N/D 99 67
f38 n-C13H27 R (b) N/D N/D 35
f39 n-C17H35 S (a) 101 91 81
f40 n-C17H35 S (b) N/D 90 62
f41 n-C17H332 S (a) N/D 45 15
f42 n-C17H332 S (b) 77 68 58
f43 n-C19H39 S (a) 64 45 10
f44 n-C19H39 S (b) N/D N/D N/D
1

a refers to the diastereomer that elutes first, b refers to the diastereomer that elutes second.

2

cis double bond located between C9 and C10 from the carbonyl.