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. Author manuscript; available in PMC: 2014 Aug 13.
Published in final edited form as: Nature. 2014 Jan 15;506(7487):240–244. doi: 10.1038/nature12883

Extended Data Figure 6. Jagged-1 inactivation in osteoblasts prevents AML of βCat(ex3)osb mice.

Extended Data Figure 6

a-d, Expression of Notch transcriptional targets in bone marrow LSK subpopulations. Rescue of changes in the proportions of e, LSK and f, erythroid cells in the bone marrow of βCat(ex3)osb/Jagged1osb+/− mice. g, Improvement of B-lymphopoiesis in βcat(ex3)osb;Jagged1osb+/− mice. Normal h, bone marrow, i, spleen and j, liver histology in βcat(ex3)osb;Jagged1osb+/− mice. k, Long bone sections. Images at 4X. In (a-d) N=4 and in (e-k) N-8 mice per group. *p < 0.05 versus WT and # p < 0.05 versus βcat(ex3)osb;Jagged1osb+/− mice. Results are mean ± SD and show a representative of three (a-d) and two (e-k) independent experiments.