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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Am J Med. 2014 Mar 19;127(7):657–663.e2. doi: 10.1016/j.amjmed.2014.01.044

Table 3. Alterations in INR Following Antibiotic Administration.

Total ≤ 4 Peak INR >4 - ≤ 6 > 6
High-risk Antibiotic (%) 22,381 20,061 (89.6) 1,748 (7.8) 572 (2.6)
 TMP/SMX 2,828 2,538 (89.7) 227 (8.0) 63 (2.2)
 Ciprofloxacin 6,844 6,195 (90.5) 514 (7.5) 135 (2.0)
 Levofloxacin 3,343 2,972 (88.9) 279 (8.4) 92 (2.8)
 Metronidazole 1,003 853 (85.0) 101 (10.1) 49 (4.9)
 Fluconazole 381 291 (76.4) 53 (13.9) 37 (9.7)
 Azithromycin 9,331 8,526 (91.4) 649 (7.0) 156 (1.6)
 Clarithromycin 584 521 (89.2) 46 (7.9) 17 (2.9)
 Co-prescribed High-risk 1,357 1,153 (85.0) 151 (11.1) 53 (4.0)
 Co-prescribed High- and Low-risk 2,401 2,089 (87.0) 226 (9.4) 86 (3.6)
Low-risk Antibiotic (%) 12,973 11,799 (91.0) 931 (7.2) 243 (2.9)

INR = International Normalized Ratio

TMP/SMX = Trimethoprim/Sulfamethoxazole