Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of MMPs through TRPV1 and Cannabinoid Receptors. TRPV1 upregulates MMP expression leading to chronic NP. CB1/CB2 upregulate AP1 and NFkβ, which then further upregulates TIMP 1-4. TIMP1-4 will in turn downregulate MMP expression. The relationship between AP1 and NFkβ and MMP is still unclear.
