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| Adverse effect | Week 1 | Week 2 | Week 3 | Week 4 | |
|---|---|---|---|---|---|
| Somnolence | 38.5% | 31.4% | 21.5% | 16.5% | |
| Dizziness | 19.4% | 16.5% | 12.4% | 11.5% | |
| Gastro-intestinal | Dry mouth | 14.5% | 12.5% | 7.5% | 4.5% |
| Constipation | 9.5% | 8.7% | 5.6% | 3.5% | |
| Diarrhoea | 4.8% | 3.2% | 2.4% | 1.5% | |
