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Ex vivo (A, 1.5T, 6-ch T/R flexcoil) and in vivo (B, 3.0T, 3” T/R loop coil) rCED infusions with similar technique. The Vd/Vi average ratio measured: in vivo (5.23 + /-1.67) compared to ex vivo (2.17 + /-1.39) was significantly larger by 2.4 times(p = 0.0017). These results support the hypothesis that an active cardiac-drivenperivascular pump improves distribution in CED.
