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. 2014 Jul 11;12:45. doi: 10.1186/s12964-014-0045-y

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Copyright © 2014 Chu et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/), applies to the data made available in this article, unless otherwise stated.

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Deregulated miRNAs in invasion and metastasis. The expression of many miRNAs involved in HCC cell invasion and metastasis are altered and affect RAS-, RHO-, and EMT-related signaling pathways. The green miRNAs may inhibit HCC cell invasion and metastasis, and the red miRNAs may promote HCC cell invasion and metastasis.