Table 3.

Correlates With Mortality in Multivariate Models

Variable	HR (95% CI)a	P Value	HR (95% CI)b	P Value	HR (95% CI)c	P Value
Age, per 10 y	1.39 (1.28–1.51)	<.001	1.38 (1.27–1.50)	<.001	1.38 (1.27–1.50)	<.001
Male sex	1.01 (0.86–1.20)	.87	0.93 (0.79–1.10)	.40	1.00 (0.85–1.18)	.99
White race	1.35 (1.10–1.65)	<.004	1.40 (1.15–1.71)	.001	1.35 (1.10–1.65)	.004
Medicaid vs other payer	1.16 (0.94–1.43)	.18	1.23 (1.00–1.51)	.05	1.15 (0.93–1.43)	.19
Current smoker	1.49 (1.06–2.10)	.02	1.47 (1.04–2.07)	.03	1.48 (1.05–2.08)	.03
Frailty	1.59 (1.27–1.99)	<.001			1.57 (1.25–1.97)	<.001
eGFR per 5 mL/min/1.73m2			1.12 (1.02–1.23)	.02	1.08 (0.98–1.19)	.11
Albumin quartiles/missing		<.001 for trend		.007 for trend		<.001 for trend
Group 1: ≤2.5 g/dL	1.48 (1.14–1.92)	.003	1.45 (1.12–1.88)	.005	1.47 (1.13–1.90)	.004
Group 2: >2.5–3.0 g/dL	1.21 (0.90–1.62)	.21	1.18 (0.88–1.58)	.26	1.21 (0.90–1.63)	.21
Group 3: missing	1.16 (0.88–1.54)	.28	1.20 (0.91–1.59)	.20	1.16 (0.87–1.53)	.31
Group 4: >3.0–3.5 g/dL	1 [Reference]		1 [Reference]		1 [Reference]
Group 5: >3.5 g/dL	0.89 (0.68–1.17)	.40	0.90 (0.69–1.17)	.42	0.89 (0.67–1.17)	.40
Hemoglobin quartiles/missing		.75 for trend		.75 for trend		.87 for trend
Group 1: ≤9 g/dL	1 [Reference]		1 [Reference]		1 [Reference]
Group 2: >9–10 g/dL	1.06 (0.81–1.38)	.68	1.06 (0.82–1.37)	.68	1.06 (0.81–1.38)	.68
Group 3: missing	1.08 (0.77–1.52)	.65	1.06 (0.76–149)	.71	1.06 (0.76–1.49)	.73
Group 4: >10–12 g/dL	1.06 (0.86–1.31)	.60	1.02 (0.82–1.26)	.88	1.03 (0.83–1.28)	.78
Group 5: >12 g/dL	1.02 (0.75–1.40)	.88	0.96 (0.70–1.33)	.82	0.98 (0.71–1.36)	.92
Hemodialysis vs PD	0.74 (0.55–0.99)	.04	0.76 (0.57–1.00)	.06	0.74 (0.55–1.00)	.05
Comorbidity
Diabetes mellitus	1.02 (0.86–1.23)	.77	1.04 (0.87–1.25)	.65	1.00 (0.83–1.20)	>.99
Congestive heart failure	1.12 (0.92–1.36)	.27	1.12 (0.93–1.36)	.24	1.11 (0.91–1.35)	.30
Atherosclerotic heart disease	1.19 (0.99–1.46)	.10	1.17 (0.96–1.42)	.11	1.19 (0.97–1.46)	.09
CVA/TIA	0.88 (0.63–1.22)	.44	0.94 (0.70–1.28)	.70	0.87 (0.63–1.21)	.41
Peripheral vascular disease	1.23 (0.97–1.56)	.09	1.25 (0.99–1.58)	.06	1.27 (0.97–1.55)	.13
COPD	1.35 (0.99–1.84)	.06	1.32 (0.98–1.78)	.07	1.32 (0.97–1.81)	.08
Cancer	1.04 (0.74–1.46)	.83	1.12 (0.80–1.56)	.51	1.04 (0.74–1.46)	.83
Erythropoietin use		.80 for homogeneity		.60 for homogeneity		.31 for homogeneity
Nonusers	1 [Reference]		1 [Reference]		1 [Reference]
Users	1.01 (0.83–1.22)	.94	1.06 (0.86–1.29)	.59	1.02 (0.84–1.24)	.85
Unknown or missing	0.92 (0.69–1.21)	.55	0.92 (0.70–1.21)	.56	0.92 (0.70–1.22)	.58
Early nephrology referral		.58 for homogeneity		.35 for homogeneity		.62 for homogeneity
No	1 [Reference]		1 [Reference]		1 [Reference]
Yes	0.98 (0.79–1.23)	.89	0.96 (0.77–1.19)	.69	0.98 (0.79–1.23)	.87
Unknown or missing	1.17 (0.80–1.69)	.42	1.20 (0.83–1.74)	.32	1.15 (0.79–1.67)	.45

Abbreviations: COPD, chronic obstructive pulmonary disease; CVA/TIA, cerebrovascular accident/transient ischemic attack; eGFR, estimated glomerular filtration rate; HR, hazards ratio; PD, peritoneal dialysis.

SI conversion factors: To convert albumin to grams per liter, multiply by 10; to convert hemoglobin to grams per liter, multiply by 10.

^aMultivariate model in which frailty but not eGFR was included among predictor variables.

^bMultivariate model in which eGFR but not frailty was included among predictor variables.

^cMultivariate model in which both eGFR and frailty were included among predictor variables.