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. 2014 Mar 10;5:e28102. doi: 10.4161/sgtp.28102

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name sgtp-5-e28102-g1.jpg — Figure 1. Intracellular trafficking of GLUT4. Intracellular compartments in which GLUT4 is localized are shown as squares. Intracellular translocation of GLUT4 between compartments is shown by thick arrows. In unstimulated cells, GLUT4 is sequestered in specialized compartments termed GSVs. GLUT4 is redistributed and becomes accumulated in the plasma membrane via various pathways when cells are stimulated with insulin. EE, early endosome; ERC, endosomal recycling compartment; GSV, GLUT4 storage vesicle; TGN, trans-Golgi network.