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. 2014 Mar 10;5:e28102. doi: 10.4161/sgtp.28102

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Copyright © 2014 Landes Bioscience

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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graphic file with name sgtp-5-e28102-g5.jpg — Figure 5. Role of TC10 downstream of the insulin receptor in adipocytes. Insulin stimulates the formation of a signaling complex consisting of CAP, Cbl, CrkII, and the GEF C3G. Activated TC10 recruits Gapex-5, a GEF for Rab31, to the plasma membrane through the interaction with CIP4. Rab31 in turn fails to be activated, and GLUT4 trafficking from ERC to GSV is released from the negative regulation by Rab31. TC10 is also implicated in the regulation of GLUT4 vesicle tethering to the plasma membrane through the interaction with the exocyst complex and actin cytoskeletal rearrangements. ERC, endosomal recycling compartment; GSV, GLUT4 storage vesicle.