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. Author manuscript; available in PMC: 2014 Jul 31.
Published in final edited form as: Nat Genet. 2011 Sep 28;43(10):925–926. doi: 10.1038/ng.956

Table 1.

Tumors with somatic mutations in BAP1

Tumor Type No. Tumors Somatic Mutations Reference
No. %
Melanocytic
 Common nevi 29 0 0.0 Wiesner et al3
 Spitz nevi 17 0 0.0 Wiesner et al3
 Atypical Spitz nevi 18 2* 11.1 Wiesner et al3
 Cutaneous melanoma 60 3 5.0 Wiesner et al3
Uveal melanoma, total 93 41 44.1 Wiesner et al3; Harbour et al1
 Wiesner et al3 study 33 13 39.4 Wiesner et al3
 Harbour et al1 study 60 28 46.7 Harbour et al1
  Low metastatic risk 26 1 3.8 Harbour et al1
  High metastatic risk 31 25 80.6 Harbour et al1
  Metastatic 3 2 66.7 Harbour et al1
Mesothelioma, total 139 28 20.1 Testa et al; Bott et al2
 Testa et al study4 18 4 22.2 Testa et al4
 Bott et al study2 121 24 19.8 Bott et al2
Breast 251 1 0.6 Forbes et al, 2008 & 20115,6
Lung 322 2 0.4 Forbes et al, 2008 & 20115,6
Ovary 59 2 3.4 Forbes et al, 2008 & 20115,6
Pancreas 30 0 0.0 Forbes et al, 2008 & 20115,6
*

These tumors had morphologic features similar to the melanocytic tumors observed in families 1 and 2 (Wiesner et al3)