Table 1.
Tumor Type | No. Tumors | Somatic Mutations | Reference | |
---|---|---|---|---|
No. | % | |||
Melanocytic | ||||
Common nevi | 29 | 0 | 0.0 | Wiesner et al3 |
Spitz nevi | 17 | 0 | 0.0 | Wiesner et al3 |
Atypical Spitz nevi | 18 | 2* | 11.1 | Wiesner et al3 |
Cutaneous melanoma | 60 | 3 | 5.0 | Wiesner et al3 |
Uveal melanoma, total | 93 | 41 | 44.1 | Wiesner et al3; Harbour et al1 |
Wiesner et al3 study | 33 | 13 | 39.4 | Wiesner et al3 |
Harbour et al1 study | 60 | 28 | 46.7 | Harbour et al1 |
Low metastatic risk | 26 | 1 | 3.8 | Harbour et al1 |
High metastatic risk | 31 | 25 | 80.6 | Harbour et al1 |
Metastatic | 3 | 2 | 66.7 | Harbour et al1 |
Mesothelioma, total | 139 | 28 | 20.1 | Testa et al; Bott et al2 |
Testa et al study4 | 18 | 4 | 22.2 | Testa et al4 |
Bott et al study2 | 121 | 24 | 19.8 | Bott et al2 |
Breast | 251 | 1 | 0.6 | Forbes et al, 2008 & 20115,6 |
Lung | 322 | 2 | 0.4 | Forbes et al, 2008 & 20115,6 |
Ovary | 59 | 2 | 3.4 | Forbes et al, 2008 & 20115,6 |
Pancreas | 30 | 0 | 0.0 | Forbes et al, 2008 & 20115,6 |
These tumors had morphologic features similar to the melanocytic tumors observed in families 1 and 2 (Wiesner et al3)