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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Am J Surg Pathol. 2014 Apr;38(4):567–577. doi: 10.1097/PAS.0000000000000127

Figure 4.

Figure 4

Peri-tumoral tubular epithelial changes in grossly uninvolved ipsilateral renal parenchyma in a patient with a high-grade renal cell carcinoma (RCC) and hereditary leiomyomatosis and renal cell carcinoma (HLRCC). (A, F) H&E; (B, G) 2SC; (C, H) GLUT1; (D) CAIX; and, (E) p53. (A-E) Aberrant renal tubular epithelial cells with a hobnail appearance, irregular macronuclei, and occasional mitotic figures (A) are present adjacent to the left renal tumor. These dysplastic cells show focal, mild accumulation of S-(2-succinyl) cysteine (2SC) (B), patchy, strong membranous expression of GLUT1 (C) and CAIX (D), and sporadic nuclear accumulation of p53 (E). (F-H) Separate irregularly shaped tubules lined by epithelial cells with clear, vacuolated cytoplasm (F) are present throughout the left renal parenchyma. These clear cells demonstrate patchy, intermediate cytoplasmic and membranous expression of GLUT1 (H) but no expression of CAIX or p53 (not shown); there is no accumulation of 2SC (G). (All images at 400X magnification.)