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. Author manuscript; available in PMC: 2014 Jul 31.
Published in final edited form as: Lab Chip. 2012 May 8;12(12):2190–2198. doi: 10.1039/c2lc21290k

Fig. 7.

Fig. 7

Line graph of HTChIP results showing ChIP enrichment of various histone marks and SIRT6 at canonical NFκB promoters in MEF cells after stimulation with TNF-α for different amounts of time. SIRT6 is recruited to NFκB promoters after 30 min of stimulation and leads to deacetylation of H3K9. This demonstrates that HTChIP is sensitive enough to track changes in enrichment levels over a fine temporal resolution, and allows tracing of many protein simultaneously, generating a holistic picture of dynamic intracellular protein-DNA interaction.