. Author manuscript; available in PMC: 2014 Jul 31.

Published in final edited form as: Curr Top Med Chem. 2008;8(2):80–100. doi: 10.2174/156802608783378891

Table 1.

List of Chemistries Used in the Immobilization of Heparin

# of Sites/ Heparin Chain	Activation with, to	Reaction with	Linkage
1	None	R-NH₂ or RNH-NH₂, NaBH₃CN R-NH₂, RNH-NH₂	RNHCH₂Hep RNHNHCH₂Hep RNHCOHep RNHNHCOHep
~ 0.3	none	RCO₂X RCOH, NaBH₃CN	RCONHHep RCH₂NHHep
~ 20		RNH₂	RNHCOHep, RNHNHCOHep
~ 60	CNBr, Hep-O-CN (or Triazine)	RNH₂	RNHCOO-Hep
~ 5		RNH₂, NaBH₃CN RNHNH₂, NaBH₃CN
~ 15		RNH₂
~ 15		RNH₂, NaBH₃CN