Table 1.

Selected Catalyst Optimization Data for Enantioselective CDC Amidation^a

entry	catalyst	conversion (%)b	ee (%)c
1	(S)-C8-TRIP	86	8
2	(S)-TCYP	95	16
3	(R)-STRIP	64	30
4	(R,R)-Ph-DAP	69	−10d
5	(S)-VAPOL PA	97	31
6	(S)-9b	99	−69
7	(S)-9g	92	−78
8	(S)-9h	92	−80
9	(S)-9i	91	−77
10	(S)-9l	75	−81
11e	(S)-9l	91(83)f	−84
12	none	82	nd

^aSee Supporting Information for complete optimization data.

^bDetermined by HPLC using 1,4-dinitrobenzene internal standard.

^cDetermined by chiral HPLC.

^dNegative sign indicates that opposite enantiomer predominates.

^ep-Xylene was used as solvent with 5 mol % catalyst.

^fValue in parentheses reflects isolated yield.