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. 2014 Jul 31;10(7):e1003741. doi: 10.1371/journal.pcbi.1003741

Figure 4. Reasonable druggable criteria from analysis of 109 co-crystal structures of MDDR oral tablet drugs.

Figure 4

A) Volumes of MDDR protein structure pockets. B) For pockets with volumes between 160 and 800 Å3, Dscore+ distribution of MDDR protein structures (top) and all protein structures (bottom). C) Range of Dscore+ after flexibility modeling of MDDR protein structure pockets supports a modified 1.7 Dscore+ cut-off after flexibility is applied.