Figure 5. Flexibility modeling substantially increases the volume of a minority of protein pockets.
A 2D histogram showing all pockets found in the mammalian structural proteome with initial volumes less than 800 Å3 and with greater than 100 amino acids (about 10 kD in weight). The vertical and horizontal white lines indicate the 160 Å3 volume cut-off. While the modeling method likely overpredicts volume increases in pockets, the majority of pockets that increase in volume increase by less than 50 Å3. The color bar on the right side indicates the number of pockets at each 2D histogram bin.