Figure 6. Predicting state transitions.

Certain features of the microcircuit measured during the presentation of the inducing stimulus carry predictive information regarding an upcoming switch to/from the persistent activity state. Blue bars: mean accuracy ± standard error, green bars: mean sensitivity ± standard error, red bars: mean specificity ± standard error. A. Predictive features for the emergence of persistent activity. B. Predictive features for the termination of persistent activity. A, B. The total spiking activity during the first 400 ms of the stimulus presentation and the filtered iGABA_B and iNMDA at a single pyramidal neuron during the 500 ms of the stimulus predict induction and termination of persistent activity.