Table 3. Evidence for association of A allele of rs660599 (chromosome 11; Base position 102,234,967) with large artery atherosclerotic stroke and all ischaemic stroke.

Subtype	SNP	RAF	p-value (discovery)	OR (95% CI) (EUR replication)	p-value (EUR replication, overall)	p-value (ALL replication, overall)
LAA	rs660599	0.19	2.5.×10−7	1.18 (1.05–1.32)	0.0048, 2.6×10−8	0.0063, 3.4×10−8
IS	“	“	3.2×10−4	1.05 (1.00–1.11)	0.050, 1.9×10−4	0.098, 3.6×10−4
CE	“	“	0.13	-	-	-
SVD	“	“	0.30	-	-	-

LAA, large artery stroke; IS, all ischaemic stroke; SNP, single nucleotide polymorphism; RAF, risk allele frequency; OR, odds ratio; 95% CI, 95% confidence interval; EUR, meta-analysis in individuals of European ancestry alone; ALL, trans-ethnic meta-analysis of all individuals. Forest plots of effect sizes and standard errors for each replication centre are given in Figures S3, S4.