Figure 3. Effect of auranofin on the survival of chicken embryos infected with RH T. gondii tachyzoites- model of acute toxoplasmosis.
A. Kaplan Meier survival curve of infected chick embryos over 5 days after treatment with auranofin with a single dose of 1 mg/kg. Additional subjects that were allowed to incubate for 8 days are included in this survival curve. B Quantification of parasite load (mean ±SD) in brains and livers of chicken embryos presented as the log10 of number of tachyzoites as determined by real-time PCR per 25 gram of tissue. Control chicken embryos: 22; auranofin-treated embryos: 19*. * Three chicken embryos that died on the day of injection due to bleeding were not included in the experiment.