Skip to main content
. Author manuscript; available in PMC: 2014 Jul 31.
Published in final edited form as: Sci Signal. 2013 Dec 3;6(304):ra105. doi: 10.1126/scisignal.2004125

Fig. 4. Inhibition of PLC-γ and PI3K reduces SCF-induced ERK phosphorylation in WT and Mx1-Cre, KrasG12D cells highly enriched for stem cells.

Fig. 4

(A to C) Bone marrow cells from WT and Mx1-Cre, KrasG12D mice were left unpretreated or were pretreated with (A) PD0325901, (B) PI-90, or (C) U73122 before being stimulated with SCF in the absence or presence of PMA. Cells were analyzed by phospho-flow cytometry to determine the abundance of pERK in KLS 48- cells. (D) Quantitation of two independent experiments.