Figure 2. Structure and topology of wild-type and mutant zebrafish Ig-like domains belonging to the α-DG C-terminal region.

The secondary structure elements (panel A) are named according to Harpaz and Chothia [46]. The β-strands are colored according to the sheet to which they belong and the N and C termini are indicated. The topology diagram of the domains is shown in panel B; β-strands are shown as circles and the small helix as a triangle.