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Management algorithm for hypersensitivity reactions to platinum agents. aApply clinical judgment according to observed symptoms. Consider consultation with an allergist, a medical oncologist, or any specialist with desensitization experience; an increase in the infusion time; use or avoidance of premedication; and use of a desensitization protocol. bDesensitization must be conducted under adequate supervision and with the necessary equipment present. po = orally; iv = intravenously.
