TABLE IV.

General principles of the 12-step desensitization protocol (adapted from Feldweg et al.⁵⁷)

Step	Solution	Rate (mL/h)	Time (minutes)	Volume infused per step (mL)
1	1:100 dilution of the final target concentration	2	15	0.5
2		5	15	1.25
3		10	15	2.5
4		20	15	5
5	1:10 dilution of the final target concentration	5	15	1.25
6		10	15	2.5
7		20	15	5
8		40	15	10
9	Usual concentration; cumulative dose administered in steps 1–8	10	15	2.5
10		20	15	5
11		40	15	10
12		75	Prolonged until complete dose	232.5