TABLE V.
Studies using the 12-step desensitization protocol
| Study | Drug | Patients (desensitizations) [N (n)] | Premedication | Steps | Duration | Success rate |
|---|---|---|---|---|---|---|
| Feldweg et al., 200557 | Paclitaxel and docetaxel | 17 (77) | Oral dexamethasone 20 mg 12 and 6 hours before infusion, intravenous diphenhydramine 50 mg and ranitidine 50 mg 30 minutes before infusion | From 1:100 to 1:1 in 12 steps | 5.8 Hours | 100% |
| Lee et al., 200567 | Carboplatin Paclitaxel Docetaxel |
31 (127) 22 (114) 1 (14) |
Intravenous diphenhydramine 25 mg, intravenous famotidine 20 mg, and lorazepam 1 mg as needed for anxiety | From 1:100 to 1:1 in 12 steps (high concentration for outpatients) | 5.8 Hours (inpatients); 3.8 hours (outpatients) | 85% of treatments without symptoms (complete initial dose with treatment) |
| Castells et al., 200841 | Cisplatin Carboplatin Oxaliplatin Paclitaxel |
3 (12) 60 (212) 1 (1) 28 (140) |
Oral or intravenous diphenhydramine or hydroxyzine 25 mg, intravenous famotidine 20 mg or ranitidine 50 mg, and oral or intravenous lorazepam 0.5–1 mg as needed for anxiety 20 minutes before infusion, and oral dexamethasone 20 mg night before and morning of paclitaxel infusion | From 1:100 to 1:1 in 12 steps | 5.8 Hours | 100% |