Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Trophic coupling between OPCs and cerebral endothelium may play an important role in the BBB function. TGF-β1 may mediate the cell-cell interaction; i.e. OPCs secrete TGF-β1, which then binds to its receptor, followed by activating MEK/ERK pathway to increase the BBB tightness.
