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. 2014 Apr 10;18(7):1290–1299. doi: 10.1111/jcmm.12280

Fig. 6.

Fig. 6

UNC5B deletion exacerbates epithelial cells apoptosis. (A) Apoptosis of colonic cell following DSS colitis in WT and UNC5B heterozygous knockout mice was determined by TUNEL assay. Quantitative data for TUNEL-positive nuclei in five 40 × fields are given below. DSS induced a large increase in apoptotic cells in WT mice, which was further increased in UNC5B heterozygous knockout mice. *P < 0.001 versus water treated and #P < 0.05 versus other groups; N = 6–8; scale bar: 100 μM. (B) Pro-apoptotic gene expression was significantly increased in UNC5B+/− with DSS as compared WT mice or water-treated control mice. *P < 0.001 versus other groups; n = 5.