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. 2014 Jun 9;42(13):8556–8564. doi: 10.1093/nar/gku523

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Repetitive RHA unwinding enhances the annealing of ssRNA to its complementary strand in dsRNA. (A) An experimental scheme for testing the annealing activity of RHA. The RNA strand (blue line) is complementary to the Cy3-labeled ssRNA (red line). (B) Single molecule surface images taken with (right) and without (left) RHA and ATP. (C) The binding-induced annealing and unwinding-mediated annealing measured for wild-type and ΔdsRBDs-RHA (top) and the enhancement factor for both proteins (bottom). (D) A diagram showing how repetitive unwinding enhances the annealing of ssRNA to its complementary strand.