Table 4. Stabilities of multimeric G-quadruplexes with different pocket sizes.
T1/2 (°C) | T1/2 (°C) | ||||
---|---|---|---|---|---|
G-quadruplex | Dilute conditions | Molecular crowding conditions | G-quadruplex | Dilute conditions | Molecular crowding conditions |
Hum21 | 60.4 | 70.6 | Hum57-M1 | 45.6 | 50.7 |
Hum45 | 45.8 | 51.5 | Hum63-M1 | 45.8 | 51.5 |
Hum51 | 47.6 | 53.1 | Hum51-M2 | 51.3 | 55.2 |
Hum57 | 49.8 | 56.0 | Hum57-M2 | 51.4 | 55.0 |
Hum63 | 51.4 | 57.4 | Hum63-M2 | 51.4 | 54.8 |
Hum69 | 48.6 | 52.2 | Hum57-M3 | 52.6 | 57.5 |
Hum51-M1 | 45.8 | 51.4 | Hum63-M3 | 52.6 | 57.6 |