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. 2014 Jul 3;42(13):8343–8355. doi: 10.1093/nar/gku561

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© The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — INXS knockdown in the non-tumor kidney cell line RC-124 reduces the BCL-XS/BCL-XL ratio. (A) INXS knockdown in the RC-124 cell line using two distinct INXS-knockdown ASOs (INXS-ASO-1 and -2) reduces by 60% the endogenous levels of INXS compared to a control scrambled oligonucleotide transfection. (B) The levels of BCL-XS (black) and BCL-XL (red) mRNA isoforms in the same cells were measured by RT-qPCR. (C) BCL-XS/BCL-XL mRNA ratio in these cells was significantly reduced from 0.25 to 0.15 upon transfection with INXS-ASO-1 and -2. The data are the mean ± SD of three independent experiments. *(P <0.05), and **(P<0.01).