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. 2014 Jul 3;42(13):8343–8355. doi: 10.1093/nar/gku561

Figure 4.

Figure 4.

INXS endogenous expression is increased by apoptosis-inducing agents and is associated with increased BCL-XS mRNA and caspases activation. (A, E, I) Induced expression of INXS lncRNA in 786-O kidney tumor cells by exposure (A) to 40 J/m2 UV-C light for 40 s at time zero, (E) to serum reduction for 24 h or (I) to sulforaphane anti-cancer drug (SFN) for up to 24 h. (B, F, J) Levels of BCL-XS (black) and BCL-XL (red) mRNA isoforms in the same cells. (C, G, K) BCL-XS/BCL-XL mRNA ratio in the cells. (D, H, L) Activation of caspase 3 and caspase 9 in 786-O cells at 24 h after the exposure to (D) 40 J/m2 UV-C, (H) 0.5% serum or (L) SFN. (See Supplementary Figure S4 for other caspases.) *(P <0.05), **(P <0.01) and ***(P <0.001).