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(A) Point mutations inserted in hras-1 and/or hras-2 of the designed mutant plasmids Mut-1, Mut-2, Mut-A, Mut-B, Mut-C and Mut-D. The sites of MAZ in hras-1 and hras-2 are signed with rectangles; (B) Scheme showing the presence of the quadruplex-forming motif (top panel) and MAZ-binding site (bottom panel) in the various plasmids. (C) % relative luciferase from wild-type and mutant plasmids.
