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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: Kidney Int. 2014 Feb 26;86(2):275–285. doi: 10.1038/ki.2014.17

Figure 2. Regulation of nitric oxide (NO) synthesis.

Figure 2

Left side: calcium-dependent, mediated by acetylcholine and bradykinin. Right side: calcium-independent, stimulated by vascular endothelial growth factor (VEGF). In pre-eclampsia, elevated levels of soluble fms-like tyrosine kinase 1 (sFlt-1) may act as a non-signaling decoy, thus interfering with VEGF-dependent phosphorylation/stimulation of endothelial NOS (eNOS).

Abbreviations: Akt, protein kinase B; Arg, arginine; cGMP, cyclic guanosine monophosphate; DAG, diacylglycerol; ER, endoplasmic reticulum; Gq-P, phosphorylated Gq protein; IP3, inositol triphosphate; PIP2, phosphatidylinositol biphosphate; PLC, phospholipase C.