Skip to main content
. Author manuscript; available in PMC: 2015 Aug 4.
Published in final edited form as: Chemistry. 2014 Jul 2;20(32):9840–9850. doi: 10.1002/chem.201402474

Figure 3.

Figure 3

Detecting enzyme activities via changes in T2 relaxation. Top Panel: A nanoassembly of Gd-based contrast agents that are linked with DEVD peptides can be disaggregated following DEVD peptide cleavage by caspase-3. Bottom Panel: The incubation of the DEVD-linked nanoassembly with caspase-3 showed an increase in T2 relaxation time, caused by disassembly. Incubation of the nanoassembly with the enzyme and a caspase-3 inhibitor further confirmed that this approach detected caspase-3 enzyme activity. Reproduced with permission from (43a).