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Myomaker is necessary for muscle regeneration. (A) Time course of tamoxifen (TMX) and CTX treatment. TA muscles were analyzed 9 d post-injury. (B) H&E-stained sections from control and myomakerscKO mice show a complete lack of regeneration after genetic deletion of myomaker in satellite cells. Bars: top image, 500 μm; bottom image, 100 μm. (C) Myosin and desmin staining revealed a dramatic loss of muscle cells and no regenerated muscle fibers in myomakerscKO TA. Bar, 20 μm.
