Table 1.
Kyoto Encyclopedia of Genes and Genomes (KEGG) terms associated with transcripts that had significant differential expression in response to RDX exposure compared to controls in a 5d experiment
| 0.5 mg/L RDX | Cor | Alg | Oth | 1.8 mg/L RDX (cont.) | Cor | Alg | Oth | 7.2 mg/L RDX (cont.) | Cor | Alg | Oth |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1. Metabolism | 14 | 0 | 0 | Pyruvate metabolism | 0 | 0 | 1 | 1.4 Nucleotide Metabolism | 1 | 1 | 0 |
| 1.1 Carbohydrate Metabolism | 5 | 0 | 0 | Glyoxylate and dicarboxylate metabolism | 1 | 0 | 0 | Purine metabolism | 1 | 1 | 0 |
| Glycolysis/Gluconeogenesis | 1 | 0 | 0 | Butanoate metabolism | 0 | 0 | 1 | 1.5 Amino Acid Metabolism | 4 | 0 | 3 |
| Citrate cycle (TCA cycle) | 2 | 0 | 0 | 1.2 Energy Metabolism | 2 | 1 | 0 | Alanine and aspartate metabolism | 0 | 0 | 1 |
| Pyruvate metabolism | 2 | 0 | 0 | Oxidative phosphorylation | 2 | 1 | 0 | Glycine, serine and threonine metabolism | 2 | 0 | 1 |
| 1.2 Energy Metabolism | 1 | 0 | 0 | 1.3 Lipid Metabolism | 0 | 0 | 3 | Valine, leucine and isoleucine biosynthesis | 1 | 0 | 1 |
| Nitrogen metabolism | 1 | 0 | 0 | Fatty acid metabolism | 0 | 0 | 1 | Lysine degradation | 1 | 0 | 0 |
| 1.3 Lipid Metabolism | 2 | 0 | 0 | Bile acid biosynthesis | 0 | 0 | 1 | 1.6 Metabolism of Other Amino Acids | 2 | 0 | 0 |
| Fatty acid metabolism | 1 | 0 | 0 | Glycerolipid metabolism | 0 | 0 | 1 | Cyanoamino acid metabolism | 1 | 0 | 0 |
| Arachidonic acid metabolism | 1 | 0 | 0 | 1.5 Amino Acid Metabolism | 3 | 0 | 3 | Glutathione metabolism | 1 | 0 | 0 |
| 1.4 Nucleotide Metabolism | 1 | 0 | 0 | Glutamate metabolism | 2 | 0 | 0 | 1.9 Metabolism of Cofactors and Vitamins | 7 | 1 | 0 |
| Purine metabolism | 1 | 0 | 0 | Alanine and aspartate metabolism | 0 | 0 | 1 | One carbon pool by folate | 1 | 0 | 0 |
| 1.5 Amino Acid Metabolism | 1 | 0 | 0 | Glycine, serine and threonine metabolism | 0 | 0 | 1 | Porphyrin and chlorophyll metabolism | 0 | 1 | 0 |
| Glutamate metabolism | 1 | 0 | 0 | Valine, leucine and isoleucine biosynthesis | 0 | 0 | 1 | Limonene and pinene degradation | 1 | 0 | 0 |
| 1.6 Metabolism of Other Amino Acids | 2 | 0 | 0 | Arginine and proline metabolism | 1 | 0 | 0 | Phenylpropanoid biosynthesis | 1 | 0 | 0 |
| Glutathione metabolism | 2 | 0 | 0 | 1.6 Metabolism of Other Amino Acids | 1 | 0 | 0 | Streptomycin biosynthesis | 1 | 0 | 0 |
| 1.7 Glycan Biosynthesis and Metabolism | 2 | 0 | 0 | Glutathione metabolism | 1 | 0 | 0 | Gamma-Hexachlorocyclohexane degradation | 1 | 0 | 0 |
| Chondroitin sulfate biosynthesis | 1 | 0 | 0 | Naphthalene and anthracene degradation | 1 | 0 | 0 | ||||
| Glycan structures - biosynthesis 1 | 1 | 0 | 0 | 2. Genetic Information Processing | 1 | 0 | 1 | Fluorene degradation | 1 | 0 | 0 |
| 2.1 Transcription | 0 | 0 | 1 | ||||||||
| 3. Environmental Information Processing | 4 | 0 | 0 | Aminoacyl-tRNA biosynthesis | 0 | 0 | 1 | 2. Genetic Information Processing | 3 | 0 | 2 |
| 3.1 Membrane Transport | 1 | 0 | 0 | 2.3 Folding, Sorting and Degradation | 1 | 0 | 0 | 2.1 Transcription | 1 | 0 | 1 |
| ABC transporters - General | 1 | 0 | 0 | Protein export | 1 | 0 | 0 | Aminoacyl-tRNA biosynthesis | 1 | 0 | 1 |
| 3.2 Signal Transduction | 3 | 0 | 0 | 2.2 Translation | 2 | 0 | 1 | ||||
| MAPK signaling pathway | 1 | 0 | 0 | 3. Environmental Information Processing | 1 | 1 | 0 | Ribosome | 2 | 0 | 1 |
| ErbB signaling pathway | 1 | 0 | 0 | 3.2 Signal Transduction | 1 | 1 | 0 | ||||
| Wnt signaling pathway | 1 | 0 | 0 | Two-component system - General | 0 | 1 | 0 | 3. Environmental Information Processing | 9 | 1 | 0 |
| Wnt signaling pathway | 1 | 0 | 0 | 3.1 Membrane Transport | 1 | 0 | 0 | ||||
| 4. Cellular Processes | 6 | 0 | 0 | ABC transporters - General | 1 | 0 | 0 | ||||
| 4.2 Cell Growth and Death | 1 | 0 | 0 | 4. Cellular Processes | 2 | 0 | 0 | 3.2 Signal Transduction | 8 | 1 | 0 |
| Cell cycle | 1 | 0 | 0 | 4.3 Cell Communication | 1 | 0 | 0 | Two-component system - General | 0 | 1 | 0 |
| 4.3 Cell Communication | 1 | 0 | 0 | Adherens junction | 1 | 0 | 0 | MAPK signaling pathway | 2 | 0 | 0 |
| Focal adhesion | 1 | 0 | 0 | Tight junction | 1 | 0 | 0 | ErbB signaling pathway | 1 | 0 | 0 |
| 4.4 Endocrine System | 1 | 0 | 0 | Wnt signaling pathway | 1 | 0 | 0 | ||||
| GnRH signaling pathway | 1 | 0 | 0 | 7.2 mg/L RDX | Cor | Alg | Oth | VEGF signaling pathway | 1 | 0 | 0 |
| 4.5 Immune System | 3 | 0 | 0 | 1. Metabolism | 26 | 7 | 8 | Calcium signaling pathway | 1 | 0 | 0 |
| Toll-like receptor signaling pathway | 1 | 0 | 0 | 1.1 Carbohydrate Metabolism | 6 | 3 | 3 | Phosphatidylinositol signaling system | 2 | 0 | 0 |
| T cell receptor signaling pathway | 1 | 0 | 0 | Glycolysis/Gluconeogenesis | 1 | 2 | 1 | ||||
| B cell receptor signaling pathway | 1 | 0 | 0 | Pentose and glucuronate interconversions | 1 | 0 | 0 | 4. Cellular Processes | 6 | 0 | 0 |
| Ascorbate and aldarate metabolism | 1 | 0 | 0 | 4.3 Cell Communication | 3 | 0 | 0 | ||||
| 5. Human Diseases | 2 | 0 | 0 | Starch and sucrose metabolism | 1 | 0 | 0 | Focal adhesion | 2 | 0 | 0 |
| 5.1 Cancers | 2 | 0 | 0 | Nucleotide sugars metabolism | 1 | 0 | 0 | Tight junction | 1 | 0 | 0 |
| Colorectal cancer | 1 | 0 | 0 | Pyruvate metabolism | 0 | 1 | 1 | 4.4 Endocrine System | 1 | 0 | 0 |
| Renal cell carcinoma | 1 | 0 | 0 | Butanoate metabolism | 0 | 0 | 1 | Melanogenesis | 1 | 0 | 0 |
| Inositol phosphate metabolism | 1 | 0 | 0 | 4.5 Immune System | 1 | 0 | 0 | ||||
| 1.8 mg/L RDX | Cor | Alg | Oth | 1.2 Energy Metabolism | 4 | 2 | 1 | Natural killer cell mediated cytotoxicity | 1 | 0 | 0 |
| 1. Metabolism | 13 | 1 | 10 | Oxidative phosphorylation | 2 | 0 | 1 | 4.6 Nervous System | 1 | 0 | 0 |
| 1.1 Carbohydrate Metabolism | 7 | 0 | 4 | Photosynthesis | 0 | 1 | 0 | Long-term potentiation | 1 | 0 | 0 |
| Glycolysis/Gluconeogenesis | 0 | 0 | 2 | Carbon fixation | 0 | 1 | 0 | ||||
| Citrate cycle (TCA cycle) | 1 | 0 | 0 | Methane metabolism | 1 | 0 | 0 | 5. Human Diseases | 1 | 0 | 0 |
| Pentose phosphate pathway | 1 | 0 | 0 | Nitrogen metabolism | 1 | 0 | 0 | 5.1 Cancers | 1 | 0 | 0 |
| Pentose and glucuronate interconversions | 1 | 0 | 0 | 1.3 Lipid Metabolism | 2 | 0 | 1 | Glioma | 1 | 0 | 0 |
| Ascorbate and aldarate metabolism | 1 | 0 | 0 | Fatty acid metabolism | 0 | 0 | 1 | ||||
| Starch and sucrose metabolism | 1 | 0 | 0 | Glycerophospholipid metabolism | 1 | 0 | 0 | ||||
| Nucleotide sugars metabolism | 1 | 0 | 0 | Arachidonic acid metabolism | 1 | 0 | 0 |
KEGG terms are matched to source sequences: Coral (Cor), Algal Symbionts (Alg), or other (Oth) for non-specific phylogenetic associations.