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. 2014 Jul 10;47(1):32. doi: 10.1186/0717-6287-47-32

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© Castro et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Histopathological changes produced by total extract and primary fractions of Cryptostegia grandiflora , qualified by a blinded pathologist. Pictures represents sections from mice ears stained with hematoxylin and eosin (40X) from: (A) Healthy group, (B) Control group (TPA, 2.5 μg/ear), (C) TPA and Indomethacin (0.5 mg/ear), (D) TPA and Cryptostegia grandiflora total extract (1.0 mg/ear), (E) TPA and Cryptostegia grandiflora ether fraction (1.0 mg/ear), and (F) TPA and Cryptostegia grandiflora dichloromethane fraction (1.0 mg/ear). The numbers 1 and 2 indicate epidermis and dermis, respectively. Arrows indicate cell infiltration into the dermis.