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. 2014 Aug 1;8:73. doi: 10.3389/fnana.2014.00073

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Copyright © 2014 Brown and Hamann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of the auditory nerve. (A) The auditory nerve fiber is divided into three distinct regions. The peripheral axonal region terminates in the organ of Corti. The soma resides in the spiral ganglion. The central axon projects to the cochlear nucleus, is myelinated with internodal myelinated regions modeled as 100 μm in length. (B) Equivalent circuit of the central portion of the auditory nerve, which has been adapted from an existing model of corpus callosum axon (Tagoe et al., 2014). The morphological and electrical values are contained in Tables 1, 2 respectively. The axon is divided into the nodal region and the internodal region. The internodal region is subdivided into the paranodal (PN) juxtaparanodal (JP) and axonal regions (axon). The nodal region expresses the voltage-dependent conductances of the I_Na (g_Na) and I_HT (g_IHT) currents as well as a leak current (g_L). Gi_LT is expressed in the JP. The axolemma of the internodal regions expresses a leak current (g_L), as does the overlying myelin (g_myl). The dotted lines enclose the leak and capacitative properties of each INR component. Internal resistance (R_a) is constant throughout the model and external resistance (R_e) is zero. The dark region represents the myelin, and only one PN and JP abutting the node are shown for clarity. g_myl and C_myl are the passive conductance and capacitance across the myelin, respectively. g_L is the passive conductance, g_L(N) refers to the passive conductance at the node, E_pas is the reversal potential for the passive conductance (V_L), and E_Na and E_K are the reversal potentials for the Na⁺ current and ILT and IHT respectively.